Futibatinib and durvalumab before bladder cancer surgery
Treatments studied
Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests two drugs (futibatinib and durvalumab) given before bladder removal surgery for people with muscle-invasive bladder cancer who cannot take standard cisplatin chemotherapy. The goal is to see if the combination shrinks the tumor and improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have muscle-invasive bladder cancer that has not spread to lymph nodes or other organs (stage II or IIIA).
- You cannot take cisplatin chemotherapy due to kidney problems, hearing loss, nerve damage, or other reasons, or you have refused it.
- Your tumor shows high levels of FGFR (a protein) based on a previous biopsy or new biopsy.
- You are healthy enough for surgery to remove your bladder and plan to have it done.
- You have not had immunotherapy for muscle-invasive bladder cancer before.
- Your kidneys, liver, and blood counts meet certain minimum levels.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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