Drug combo before bladder or ureter surgery for advanced cancer
Treatments studied
Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests two drugs, enfortumab vedotin and pembrolizumab, given before surgery to remove the bladder or ureter in people with advanced bladder or upper urinary tract cancer that has spread to lymph nodes or other organs. The goal is to see if this treatment helps shrink the cancer and improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have advanced bladder or upper urinary tract cancer that has spread to lymph nodes or other organs, diagnosed within the last 90 days.
- You are willing and able to have surgery to remove the bladder or ureter if the treatment works well.
- You have not had chemotherapy for bladder cancer before.
- Your kidney function is adequate (eGFR at least 15).
- You have not had prior treatment with certain immunotherapy drugs (like PD-1 or PD-L1 inhibitors).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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