Gentamicin injections for hereditary ichthyosis
Treatments studied
Part of Genetic & congenital, Skin clinical trials.
This study tests whether an antibiotic called gentamicin, given as an injection, can improve symptoms of hereditary ichthyosis, a genetic skin condition that causes severe dryness and scaling. If you have moderate to severe ichthyosis due to certain gene changes, this treatment might help your skin produce the missing proteins.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (18 or older) with a confirmed hereditary ichthyosis caused by a specific gene change (like TGM1 or PNPLA1).
- Your ichthyosis is moderate to severe, meaning it affects at least two areas of your body (like back, arms, legs, or feet) with significant scaling.
- You have not used an aminoglycoside antibiotic (like gentamicin) in the last 3 months.
- You do not have serious kidney problems, hearing loss (unless caused by earwax), or certain other medical conditions (like heart failure, cirrhosis, or muscle disorders).
- If you are a woman who could become pregnant, you agree to use effective birth control during the study, and you are not currently pregnant or breastfeeding.
- You are willing to keep your current skin treatments (like moisturizers or retinoids) stable for a few weeks before starting the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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