Azenosertib for recurrent uterine serous cancer
Treatments studied
Part of Cancer, Women’s health & pregnancy clinical trials.
This trial is testing an oral drug called azenosertib for a type of uterine cancer that has come back or spread. It aims to see if blocking a DNA repair pathway can shrink tumors or slow their growth.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a type of uterine cancer called uterine serous carcinoma (or a cancer with a serous part).
- You have already had one round of platinum-based chemotherapy (like carboplatin or cisplatin).
- If your tumor has a high MSI or MMR deficiency, you must have tried a PD-1/PD-L1 immune checkpoint inhibitor, or be unable to take one.
- You are 18 years or older, and your overall health (ECOG score) is 0, 1, or 2 (able to do light activities or be up and about).
- You are willing to have a biopsy before and during treatment, if you have a safe tumor that can be biopsied.
- You have not taken a cell cycle checkpoint inhibitor (like Wee1 or ATR inhibitors) before.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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