Clin2
NCT06371586Worth exploringRecruiting

Neo-Sequence 2: New drug combo for advanced stomach cancer

Gastric CancerDiffuse Type Carcinoma

Part of Cancer, Digestive system clinical trials.

This trial tests a new treatment plan for advanced stomach cancer using chemotherapy, anti-angiogenesis therapy (to cut off tumor blood supply), and immunotherapy (to help your immune system fight cancer). The goal is to see if this combination works better before surgery.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
67 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You have locally advanced diffuse or mixed type stomach cancer confirmed by biopsy and imaging.
  • Your cancer has not spread to distant organs and is stage T3-4NanyM0 (AJCC 8th edition).
  • You have not had any prior anti-cancer treatment for stomach cancer.
  • You are between 18 and 75 years old.
  • You are in good general health (ECOG score 0 or 1) and have adequate organ function.
  • You do not have serious medical conditions like uncontrolled infections, autoimmune diseases, or other cancers.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06102772Recruiting
Combination immunotherapy and targeted therapy for advanced gastric cancer

This trial tests a combination of three drugs—adebrelimab (an immunotherapy), fruquintinib (a targeted therapy to cut off blood supply to the tumor), and a chemotherapy (paclitaxel or albumin-bound paclitaxel)—in people with advanced stomach/gastric cancer whose disease has worsened after one prior chemotherapy. The goal is to see if this new mix can help control the cancer.

Tianjin, Tianjin Municipality
NCT06791148Recruiting· Phase 2
Low-dose radiation plus chemo and immunotherapy for advanced stomach cancer

This trial tests a combination of low-dose radiation, chemotherapy, and an immunotherapy drug (AK112) for people with advanced stomach or gastroesophageal junction cancer that has progressed after first-line treatment. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.

Nanjing, Jiangsu
NCT07818070Not yet recruiting· Phase 3
New combination treatment for advanced stomach cancer

This trial tests a new drug (ONO-4578) combined with the usual immunotherapy (nivolumab) and chemotherapy for stomach cancer that has not been treated before. It aims to see if adding this drug helps shrink tumors or slows disease growth better than placebo.

NCT06339216Not yet recruiting· Phase 2
Combination therapy for advanced stomach cancer after immunotherapy

This trial tests a combination of three drugs (adebrelimab, apatinib, and paclitaxel) for people with advanced stomach or gastroesophageal junction cancer that has progressed after immunotherapy. The goal is to see if this combination helps control the cancer longer.

NCT06349967Not yet recruiting· Phase 2
Second-line treatment for advanced stomach cancer

This trial tests a combination of two drugs—nab-paclitaxel (a chemotherapy drug) and cadonilimab (an immunotherapy drug)—for people with advanced stomach cancer that has spread to the lining of the abdomen. The goal is to see if this combination can help shrink or control the cancer when other treatments haven't been tried yet.

NCT07431281Recruiting· Phase 3
New drug combo for advanced stomach cancer with CLDN18.2

This trial tests a new drug combination for people with advanced stomach cancer that has not been treated before. It looks at two groups: one with PD-L1 (a protein that helps decide if immunotherapy works), and one without. The treatment includes an antibody-drug conjugate (Sonesitatug Vedotin) plus standard chemotherapy, with or without an immunotherapy drug.

Birmingham, Alabama

Hear when a new Gastric Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.