Clin2
NCT06404320Possibly a fitRecruiting

Exercise program for treatment-resistant depression

Treatment-resistant DepressionMajor Depressive Disorder

Part of Mental health clinical trials.

This study tests whether a physical activity program can help adults whose depression hasn’t improved after trying at least two antidepressants. If you’re sedentary, between 18 and 65, and have treatment-resistant depression, this program might offer a new way to feel better through exercise.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
30 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You are between 18 and 65 years old, and currently get less than 60 minutes of moderate to vigorous physical activity each week.
  • You have major depression (without psychotic features) and are currently in a depressive episode.
  • You have tried at least two different antidepressants for your current depression, and they haven’t worked well enough.
  • You must not have any heart problems or other medical conditions that make exercise unsafe, and you must not be pregnant.
  • You own a smartphone and have reliable internet access.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06110897Recruiting
Resistance Exercise for Depression Trial

This study tests whether resistance exercise (like lifting weights) can help reduce depression symptoms. If you have major depression and are not already doing regular resistance training, you may be able to join.

Ames, Iowa
NCT06450704Recruiting
Exercise for depression: brain and body health

This trial tests if a 12-week exercise program can reduce inflammation and improve brain function in people with depression. It's for adults currently taking antidepressant medication and looking for extra help through physical activity.

Alcalá de Henares, Madrid
NCT05051618Recruiting
Exercise program for depression in people with multiple sclerosis

This trial studies whether a structured exercise program can help reduce symptoms of major depressive disorder in people who also have multiple sclerosis. You’ll complete questionnaires, wear an activity sensor, and do exercise testing while being assigned to the study program.

Chicago, Illinois
NCT07221929Recruiting
Exercise plus CBT for depression: The CBT+ Trial

This study tests whether adding exercise before standard talk therapy (CBT) helps treat depression more effectively than CBT alone. You will be asked to do moderate exercise and then receive CBT sessions over 8 weeks.

Madison, Wisconsin
NCT06732089Recruiting
Digital help for stubborn depression

This trial tests a digital program (smartphone app or website) to help people with tough-to-treat depression. If you are already receiving advanced treatments like rTMS, ketamine, or ECT at St. Michael's Hospital, you may be able to join and see if this extra digital support improves your mood.

Toronto, Ontario
NCT06594588Recruiting
Aerobic exercise for depression in adults

This trial tests whether adding a personalized aerobic exercise program to your usual depression treatment can help you feel better. It is for adults aged 18-45 with depression who are not currently in regular psychotherapy.

Beijing, Beijing Municipality

Hear when a new Treatment Resistant Depression trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.