Licorice root gel for root canal infection
Treatments studied
Part of Mouth & dental clinical trials.
This trial tests a natural anti-inflammatory medicine called glycyrrhizin (from licorice root) used inside the tooth during root canal treatment. It aims to see if it helps kill bacteria and reduce infection better than standard medications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You need a single-rooted tooth (like a front tooth) that has a dead nerve (pulp necrosis) and a related infection at the root tip (apical periodontitis).
- You must not have taken any antibiotics in the last 3 months.
- You must not have any ongoing health conditions that affect your whole body (like diabetes or heart disease).
- The tooth must be able to be isolated with a rubber dam during treatment.
- The tooth should not have deep gum pockets (more than 3 mm).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests a natural gel made from asiaticoside (a compound from the Gotu kola plant) placed inside your root canal after cleaning. This gel may help reduce infection and inflammation better than standard medicines.
This trial tests whether a special anti-inflammatory gel (diclofenac sodium) placed inside the tooth can help treat an infection at the root tip. It is for adults with a restorable tooth and no allergies to the medication.
This trial tests whether a natural gum resin (Boswellia) placed inside the tooth during root canal treatment can fight infection better than standard medications. It may be a good option for people with a single-rooted tooth infection who are otherwise healthy.
This study compares two different gels placed inside a tooth after root canal treatment to see which one works better at killing bacteria and reducing pain afterward.
This trial tests whether adding a common anti‑inflammatory gel (diclofenac) to the tooth after a root canal can reduce pain and swelling. They will also see if adding another ingredient (hyaluronidase) makes it work even better.
This trial compares two types of medicine placed inside the tooth after cleaning to see which one reduces pain better. It is for adults with a dead nerve in a lower premolar tooth who are otherwise healthy.
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