Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,635
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania21
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT06955884Recruiting
Awake breathing tube: mouth vs. nose
This trial compares two ways of placing a breathing tube in patients who have a difficult airway and need surgery. One method goes through the mouth, the other through the nose, both while you are awake. The goal is to see which method you prefer.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT07648212Recruiting
AI Tool for Detecting Tooth Decay in Dental Training
This study tests whether artificial intelligence can help dental students and residents better detect early tooth decay (cavities) between teeth. Participants will learn to use an AI tool and compare it to traditional detection methods to see if it improves accuracy.
Ann Arbor, MichiganAges 18–99 - NCT07038343RecruitingPhase 1/Phase 2
Testing a new drug for advanced solid tumors
This trial tests a new drug called AVZO-1418, either alone or with other treatments, for people with advanced solid tumors that have spread or cannot be removed. The goal is to see if the drug is safe and effective against certain types of cancer.
Gilbert, ArizonaAges 18–75 - NCT06589804RecruitingPhase 3
Testing cetuximab plus pembrolizumab for advanced head and neck cancer
This trial tests whether adding cetuximab to the standard drug pembrolizumab works better for head and neck cancer that has spread or come back after treatment. It is for people whose cancer did not respond to platinum chemotherapy and whose tumors have a certain immune marker (PD-L1).
Little Rock, ArkansasAges 18 years+ - NCT06449443RecruitingTeam says not enrolling
New MRI for Upper Jaw and Sinus Images
This study tests a new type of MRI (called zero echo time) to see if it can take clear pictures of the sinuses and teeth in the upper jaw, without using radiation. It may be an option for people who are missing back teeth and already have a CT scan of that area.
AnkaraAges 18 years+ - NCT07541625Recruiting
Digital scanning for custom tooth attachments
This research tests whether advanced scanning technology improves the fit of custom attachments placed inside root-canal-treated teeth to support dentures. If you have some remaining teeth that need support and are considering a denture, this trial may help you get a better-fitting solution.
Giza, الجيزةAges 18–65 - NCT07162753Recruiting
Ethnic bias check in AI orthodontic diagnosis
This trial checks if an AI system for orthodontic diagnosis works equally well for people of different ethnic backgrounds. You may be eligible if you have a side-view face photo taken before braces or similar treatment.
Istanbul, FatihAges 4 years+ - NCT07195734RecruitingPhase 2
Adding chemo or immunotherapy before surgery for advanced head and neck cancer
This trial tests whether giving chemotherapy or chemotherapy plus immunotherapy before surgery can improve outcomes for people with advanced head and neck cancer that has come back or not gone away after prior treatment.
Tucson, ArizonaAges 18 years+ - NCT07404865RecruitingPhase 3
Telitacicept for active primary Sjögren's disease
This study tests an investigational drug called telitacicept for people with active primary Sjögren's disease. The goal is to see if it can reduce symptoms like joint pain, fatigue, and swelling better than a placebo.
Chandler, ArizonaAges 18–75 - NCT07137052Recruiting
Precise adaptive radiotherapy for nasopharyngeal cancer
This trial tests a more precise form of radiation therapy (adaptive radiotherapy) for nasopharyngeal cancer. It is designed for patients who have not yet had any treatment and whose cancer is limited to the head and neck area.
XiamenAges 18–70 - NCT07219420RecruitingPhase 3
Study of bimekizumab for palmoplantar pustulosis
This trial tests a drug called bimekizumab for people with palmoplantar pustulosis (PPP), a skin condition causing painful pustules on the palms and soles. The goal is to see if the drug can clear these pustules and improve symptoms.
Birmingham, AlabamaAges 18 years+ - NCT05494346Recruiting
Seawater nasal spray with essential oils for blocked nose
This trial tests whether a seawater nasal spray (with essential oils) is safe and works well for people ages 12+ who have sudden (acute) cold- or allergy-related nasal blockage. You may be able to join if you can use the spray as instructed and complete simple monitoring and questionnaires.
Blainville-sur-OrneAges 12 years+ - NCT06619574Recruiting
Testing the dental compass for jaw joint positioning
This study tests a new tool called a Dental Compass that helps dentists place your jaw joint back in the right position more accurately and quickly. It may help relieve TMJ pain and improve jaw function.
Gainesville, TexasAges 18–90 - NCT06982898Recruiting
Digital jaw recording for missing back teeth
This study tests a new digital method to record how your upper and lower jaws fit together when you are missing back teeth. It may help make your dental treatment more accurate and comfortable.
AnkaraAges 18–65 - NCT06948162Recruiting
Dental MRI for routine dental care
This study tests whether a special MRI machine can take detailed images of teeth and jaws for routine dental care. It may help find problems without using X-rays.
Minneapolis, MinnesotaAges 18 years+ - NCT06580210Recruiting
Seawater spray with essential oils for stuffy nose
This trial tests a seawater and essential oil spray to clear a stuffy nose caused by a cold, sinus infection or allergies. The spray is meant to help you breathe easier without strong medicines.
BayeuxAges 12 years+ - NCT07781358RecruitingPhase 2
Testing a new drug combination for recurrent nasopharyngeal cancer
This trial tests a new drug combination for people whose nasopharyngeal cancer has come back in the same area or nearby lymph nodes. The goal is to see if this treatment can shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07781566Recruiting
Speech therapy intensity for cleft palate speech errors in children
This study looks at how well two different intensities of speech therapy work for children with a cleft palate who have speech sound errors. It aims to find the best way to help your child speak more clearly.
Ghent, East-FlandersAges 4 years+ - NCT04178174RecruitingPhase 3
Boost radiation for HPV throat cancer with shorter treatment
This trial studies whether adding a precise “extra boost” to radiation can work as well as (or better than) standard radiation for HPV-related oropharynx cancer, while keeping the overall treatment shorter. It may help improve tumor control while aiming for manageable side effects.
London, OntarioAges 18 years+ - NCT07706647Recruiting
Oil pulling for gum health trial
This study tests if oil pulling (swishing oil in your mouth) can reduce gum inflammation and bleeding. It compares oil pulling to a standard mouthwash to see which is better for gum health.
San Antonio, TexasAges 18–70 - NCT04901234RecruitingPhase 2
Adaptive radiation for advanced throat cancer
This study tests an approach called “adaptive radiotherapy,” where the radiation plan may be adjusted based on how your tumor and anatomy look during treatment. It is for adults with biopsy-proven oropharyngeal (throat) squamous cell carcinoma who are planning curative radiation, with or without chemotherapy.
MelbourneAges 18 years+ - NCT07775378Recruiting
Boron and inflammation in gum disease
This study looks at how boron levels, oxidative stress (cell damage), and inflammation (swelling) relate to periodontitis (severe gum disease). It may help understand what causes gum disease and could lead to better treatments.
Istanbul, MaltepeAges 18–65 - NCT07775365Recruiting
AI predicts gum coverage from photos
This study uses an artificial intelligence (AI) system to look at close-up photos of your gums and predict how well a gum graft procedure might work to cover receded gums. It aims to help doctors plan your treatment more accurately.
Istanbul, IstanbulAges 18–65 - NCT07273968Recruiting
Virtual reality for anxiety during wisdom tooth extraction
This study tests whether wearing a virtual reality headset during wisdom tooth removal can help reduce anxiety. It is for generally healthy adults who are having multiple wisdom teeth extracted.
StrasbourgAges 18–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,948 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.