Clot-busting treatment plus blood thinners for severe leg clots
Part of Blood & lymphatic clinical trials.
This trial tests whether combining a clot-busting procedure (pharmaco-mechanical thrombolysis) with standard blood thinners works better than blood thinners alone for people with severe, recently formed deep vein clots in the upper leg.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a blood clot in the iliac or common femoral vein (in your upper thigh or groin).
- Your clot is recent: found on imaging within the last 14 days, or symptoms started within the last 21 days.
- You have at least one severe symptom: severe leg pain (score 5 or more on a 0-10 pain scale), leg pain when walking, or your thigh is at least 5% larger than your healthy leg.
- You are 18 or older, not pregnant, and not under legal guardianship.
- Your kidneys work well enough (creatinine clearance above 30 mL/min).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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