OXiris for abdominal septic shock (OASES study)
Part of Infections, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests a special blood-filtering device (OXiris) for people with severe abdominal infections that cause septic shock and kidney damage. It aims to see if this treatment can help control the infection and improve recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and weigh at least 30 kg (about 66 pounds).
- You have a severe infection in your belly area (like an abdominal infection) that is caused by Gram-negative bacteria (a type of bacteria that can cause serious infections).
- You have septic shock, meaning your blood pressure is very low and you need medicine (like norepinephrine) to keep it up, and your lactate levels are high.
- You are on a moderate to high dose of norepinephrine (at least 0.4 micrograms per kilogram per minute).
- Your blood tests show very high levels of either procalcitonin (PCT) or interleukin-6 (IL-6), which are markers of severe infection or inflammation.
- You have acute kidney injury (sudden kidney damage) that is moderate to severe (stage 2 or 3).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks back at how a special kidney filter called oXiris helped patients in the ICU who had septic shock (a life-threatening blood infection) and kidney failure. Researchers want to understand if this filter improved survival and recovery compared to standard treatment.
This trial tests a special blood filter called Oxiris that may help remove toxins and inflammation from the blood in patients with septic shock. It aims to see if this treatment can improve outcomes for people who need kidney replacement therapy.
This study tests a special blood filter (Oxiris) to see if it helps clean the blood in people with septic shock. If you are receiving blood purification therapy, this filter might help your body recover better.
This trial tests a special blood filter (hemoadsorption) for people in septic shock (a severe infection causing very low blood pressure). It aims to see if the filter helps remove harmful substances from the blood and improve recovery.
This trial tests a special blood-filtering method (adaptive blood purification) for people with septic shock caused by a severe infection. It aims to see if this treatment can help control inflammation and improve recovery in the ICU.
This study compares two types of filters used during continuous kidney replacement therapy in patients with septic shock and severe acute kidney injury. The goal is to see which filter works better and is safer.
Hear when a new Septic Shock trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.