Clin2
NCT06534437Possibly a fitRecruiting

Study of MEN1703 for aggressive B-cell lymphoma

Non-Hodgkin Lymphoma, B-cell

Treatments studied

Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.

This trial tests a new drug called MEN1703, alone or with another drug (glofitamab), for people with aggressive B-cell non-Hodgkin lymphoma that has come back or not responded after at least two prior treatments. The goal is to see if it can help shrink tumors.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
178 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have a type of aggressive B-cell lymphoma (like DLBCL) that has come back or not responded to at least two prior treatments.
  • You have at least one tumor that can be measured on a CT or PET scan.
  • You have not had a specific type of immunotherapy called an anti-CD3xCD20 bispecific antibody (unless you are in a specific group that allows it).
  • You are generally healthy enough for daily activities (ECOG score 0, 1, or 2).
  • Your kidney, liver, and blood counts are within acceptable ranges.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07184788Not yet recruiting· Phase 2
New drug combination for lymphoma that has not responded

This study tests a new combination of drugs for people with aggressive B-cell lymphoma that has not gotten better or has come back. The goal is to see if the combination helps control the cancer.

NCT07748364Not yet recruiting· Phase 2
Glofitamab for aggressive B-cell lymphoma with biopsy-guided monitoring

This trial tests a drug called glofitamab for people with aggressive B-cell lymphomas (like DLBCL or mantle cell lymphoma) that have come back or not responded to standard treatments. The study uses a biopsy during treatment to see how the drug is working, aiming to make treatment more personalized.

New York, New York
NCT05806099Recruiting· Phase 1/Phase 2
Study of MBS303 for CD20-positive B-cell lymphoma that returned

This trial tests a medicine called MBS303 to see how safe it is and how well it works in adults with B-cell non-Hodgkin lymphoma (NHL) that has come back or did not respond to prior anti-CD20 treatment. It may help people who have few or no treatment options expected to improve survival.

Beijing
NCT07613788Not yet recruiting· Phase 2
Studying combined targeted therapies for large B-cell lymphoma

This trial tests a combination of two immunotherapy drugs (rimegepant and glofitamab) plus a special cell therapy called CD19 CAR-T for people with large B-cell lymphoma that has not responded to or has returned after previous treatment. The goal is to see if this combination can better control the lymphoma and improve outcomes.

Shanghai, China
NCT07308132Recruiting· Phase 1
Study of a new drug for B-cell lymphoma

This study tests an experimental drug for people with B-cell non-Hodgkin lymphoma (a type of blood cancer) that has come back or hasn't responded to standard treatments. The goal is to see if the drug is safe and can shrink the cancer.

Clayton
NCT07702851Not yet recruiting· Phase 2
Study of two new drugs for people with large B-cell lymphoma that returned or didn't respond to first treatment

This trial tests a combination of two targeted drugs, polatuzumab vedotin and glofitamab, for people with large B-cell lymphoma that came back or didn't go away after their first standard treatment. The goal is to see if this combination can help control the lymphoma.

Hear when a new Non-Hodgkin Lymphoma, B-cell trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.