Immunotherapy plus prebiotic foods for melanoma before surgery
Part of Cancer, Skin clinical trials.
This study tests if eating certain prebiotic foods while receiving immunotherapy before melanoma surgery can boost your immune system and improve treatment response. Participants eat study-provided foods and receive standard immunotherapy (ipilimumab with or without nivolumab, or nivolumab with or without relatlimab).
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have a body mass index (BMI) between 18.5 and 45.
- You have a type of skin or mucosal melanoma that can be surgically removed and is at least stage IIIB or limited stage IV.
- You are scheduled to start immunotherapy (ipilimumab + nivolumab, or nivolumab alone, or nivolumab + relatlimab) before surgery.
- You are willing to eat the study-provided foods and follow dietary instructions, including stool and blood sample collection.
- You are not on high-dose steroids, have no inflammatory bowel disease or prior bariatric surgery, and do not have insulin-dependent diabetes.
- You have not used antibiotics recently, do not smoke or drink heavily, and are not pregnant or planning pregnancy.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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