PD-1 inhibitor plus progesterone for fertility preservation in MMRd endometrial cancer
Part of Cancer, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This trial tests a combination of an immunotherapy drug (PD-1 inhibitor) and progesterone hormone therapy to treat early-stage, MMR-deficient endometrial cancer while preserving fertility. It may help young women who want to keep the option to have children in the future.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 45 years old.
- You have been diagnosed with stage IA endometrial cancer (the earliest stage) that is grade 1 or 2 (less aggressive).
- Your tumor is MMR-deficient, which means it has a specific genetic feature that may respond better to immunotherapy.
- You have a strong desire to preserve your fertility (keep the ability to get pregnant).
- You have not had any other cancer, and you are not currently pregnant or unable to become pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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