Clin2
NCT06577376Possibly a fitNot yet recruiting

Combination therapy for advanced stomach cancer

Localized Advanced or Metastatic Gastric Adenocarcinoma or Gastroesophageal Junction AdenocarcinomaExpressing Human Epidermal Growth Factor Receptor-2 (HER-2)Disease Progression After Receiving at Least One and at Most Two Lines of Systemic Treatment in the Past

Treatments studied

Part of Cancer, Digestive system clinical trials.

This trial tests a new drug combination for people with advanced stomach or gastroesophageal junction cancer that has grown after earlier treatment. It aims to see if adding these drugs can help shrink tumors or slow the disease.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
252 people
Ages
18 years to 75 years
Study type
Interventional

Who can take part

  • You are between 18 and 75 years old.
  • You have stomach or gastroesophageal junction cancer that has spread or cannot be removed by surgery.
  • Your cancer has gotten worse after one or two lines of treatment, and your first treatment included a platinum drug and a fluorouracil drug, with or without an immunotherapy drug.
  • You have at least one tumor that can be measured on a scan.
  • Your cancer has a certain level of HER2 protein (2+ or 3+ for one group, or 1+ for another group).
  • Your organs and bone marrow are working well enough to receive the study treatment.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07655661Not yet recruiting· Phase 2
Combination treatment for advanced stomach cancer

This trial tests a new combination of drugs for advanced stomach cancer that has spread or come back. It aims to see if adding an immune therapy and a bacterial extract to standard chemotherapy can help control the cancer better.

Chengdu, Sichuan
NCT07594548Not yet recruiting· Phase 1
Combination therapy for advanced stomach or esophagus cancer

This trial tests a combination of three drugs for advanced stomach or esophagus cancer that hasn't been treated much. The goal is to see if this combination helps shrink or control the cancer.

Chicago, Illinois
NCT06415669Recruiting· Phase 2
Combination therapy for advanced stomach cancer after immunotherapy

This study tests a combination of two drugs (paclitaxel, a chemotherapy, and apatinib, a targeted drug) with an immunotherapy (adebrelimab) for advanced stomach cancer. It may be an option if you've already tried immunotherapy and need a new approach.

Fuzhou, Fujian
NCT06102772Recruiting
Combination immunotherapy and targeted therapy for advanced gastric cancer

This trial tests a combination of three drugs—adebrelimab (an immunotherapy), fruquintinib (a targeted therapy to cut off blood supply to the tumor), and a chemotherapy (paclitaxel or albumin-bound paclitaxel)—in people with advanced stomach/gastric cancer whose disease has worsened after one prior chemotherapy. The goal is to see if this new mix can help control the cancer.

Tianjin, Tianjin Municipality
NCT07609667Not yet recruiting· Phase 2
Combination therapy for advanced stomach or gastroesophageal cancer

This trial tests a new combination of drugs for advanced stomach or gastroesophageal junction cancer that has not been treated before. The goal is to see if the combination can shrink tumors or slow the cancer's growth.

Beijing, Beijing Municipality
NCT07507526Not yet recruiting· Phase 2
Combination therapy for advanced her2-positive stomach cancer

This trial tests a combination of three drugs—disitamab vedotin, tunlametinib, and a PD-1 antibody—for people with advanced stomach cancer that has HER2 (a protein that helps cancer grow). The goal is to see if this combo can shrink tumors or slow the cancer, and whether it's safe.

Guangzhou, Guangdong

Hear when a new Localized Advanced or Metastatic Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.