Combination therapy for CLDN18.2-positive advanced stomach cancer
Part of Cancer clinical trials.
This study tests a combination of three drugs (LM-302, Candonilimab, and Capecitabine) as the first treatment for advanced stomach cancer that has a specific protein (Claudin 18.2). It aims to see if the combination shrinks tumors and is safe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery.
- Your tumor tests positive for a protein called Claudin 18.2 (at least 10% of cells).
- You have not had chemotherapy or radiation for advanced cancer before (prior treatment only allowed if it ended more than 6 months ago).
- You are generally well enough to be up and about (ECOG score 0 or 1).
- Your kidneys, liver, and blood counts are within safe ranges based on recent blood tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of three drugs (given through a vein and a pill) plus a chemotherapy infusion directly into your belly for stomach cancer that has spread to the lining of the abdomen. It specifically looks at a marker called Claudin 18.2 to see if this treatment works better for people with that marker.
This Phase 2 trial tests a combination anti-cancer medicine (LM-302) plus other anti-tumor treatments for advanced gastrointestinal cancers. It’s designed for people whose tumors test positive for CLDN18.2 and who have already tried standard first-line treatment but didn’t respond or couldn’t tolerate it.
This trial tests a three-drug combination (anlotinib, TQB2450, and nab-paclitaxel) for people with advanced stomach or gastroesophageal junction cancer that is HER2-negative and has progressed after prior treatment with a CLDN18.2-targeted regimen. The goal is to see if this new combination can shrink tumors and help patients live longer.
This Phase 2 study tests new combination treatments for advanced stomach or stomach-esophagus junction cancer that cannot be removed by surgery. It may help people whose tumors are positive for a marker called Claudin18.2, which the study uses to choose who can receive the treatment.
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