Drug combination for stomach cancer with abdominal spread
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of chemotherapy drugs (LM-302, S-1, and paclitaxel) with or without an immune-boosting drug (cadonilimab) for gastric cancer that has spread to the abdominal lining. The goal is to shrink tumors and improve survival in patients whose cancer cells show a specific protein marker called Claudin 18.2.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Confirmed gastric or gastroesophageal junction cancer (no prior surgery on primary tumor or metastases)
- Cancer has spread to the abdominal lining (peritoneal metastases), confirmed by laparoscopy
- Claudin 18.2 protein present on your cancer cells (at least 25% of cells, moderate to strong staining)
- Overall health status allowing normal activities with some limitations (ECOG score 0–1)
- Expected to live longer than 3 months
- Adequate bone marrow, liver, and kidney function based on blood and lab tests
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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