Asciminib for second-line chronic phase CML
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This study tests a pill called asciminib for people with chronic phase CML whose first targeted therapy didn't work or caused side effects. The goal is to see if asciminib can better control the disease with fewer problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- You have chronic phase CML that is Philadelphia chromosome–positive or BCR-ABL–positive.
- You have already tried one TKI (targeted therapy) for CML, but it did not work well enough or caused problems that made you stop.
- You have a performance status score of 0, 1, or 2 (meaning you are up and around most of the day).
- Your liver, kidneys, and pancreas are working within safe limits (your doctor will check this with blood tests).
- You do not have a known T315I mutation, severe heart problems, active infections like HIV or hepatitis, or recent pancreatitis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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