Stem cell transplant for hard-to-control Crohn’s disease
Treatments studied
Part of Digestive system clinical trials.
This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 13 and 28 years old
- Have confirmed Crohn’s disease that has been present for at least 6 months
- Have active Crohn’s disease now (high inflammation and signs seen by scans/endoscopy/biopsy)
- Have tried several standard Crohn’s medicines (including steroids plus several immunosuppressants/biologics) without enough success or due to side effects
- Be unable to have surgery safely (or be at risk of serious short-bowel problems if surgery is needed)
- Be willing to sign consent and complete extra study visits/tests after counseling
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests whether a transplant using your own stem cells can calm active Crohn’s disease that hasn’t improved with standard medicines. It may help some people with ongoing inflammation and symptoms after multiple Crohn’s treatments.
This trial tests whether a stem cell transplant from a partially-matched family or unrelated donor can help treat severe Crohn's disease that has a known or suspected genetic cause or does not get better with standard treatments.
This trial tests whether injecting donated stem cells into complex anal fistulas can help heal them in people with Crohn's disease. You may qualify if you have a fistula that hasn't improved with standard treatments.
This study tests if a standardized fecal transplant is safe and helpful for adults with moderately to severely active Crohn's disease who are already on maintenance therapy. The goal is to see if this treatment can reduce inflammation in the digestive tract.
This study looks at people with Crohn's disease that is hard to treat. It aims to understand the disease better and see how well current treatments work.
This study tests whether transferring healthy gut bacteria from stool into the colon can work as a first treatment for children newly diagnosed with mild-to-moderate Crohn’s disease. It may help reduce inflammation and improve symptoms, and it requires regular colonoscopy to monitor progress.
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