TIPS with half-dose Donafenib for liver cancer with portal hypertension
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a treatment that combines a procedure called TIPS with a targeted therapy drug (Donafenib) at half strength. It is for people with advanced liver cancer that has spread into the portal vein and caused high blood pressure in the liver (portal hypertension). The goal is to see if this combination can help control the cancer and reduce complications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must have liver cancer (hepatocellular carcinoma) that has not been treated before.
- Your cancer must be advanced and have caused a blood clot in the main vein of your liver (portal vein tumor thrombus), leading to high blood pressure in that area.
- You should be in generally good health (able to do daily activities) and have at least 3 months to live.
- Your blood cell counts, liver and kidney function must be within certain ranges.
- You should have had a complication from portal hypertension, like bleeding in your stomach or esophagus, or a large amount of fluid in your belly that does not go away easily.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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