Molecular markers for radiation response in breast cancer

This trial tests a new way to predict whether radiation after lumpectomy will help women with DCIS, a very early form of breast cancer. You'll take a test called DCISionRT that looks at your cancer's biology, then you'll be randomly assigned to either get radiation or not, so doctors can learn who really needs it.

This study looks at breast cancer samples taken by biopsy to see how tissue “molecular markers” relate to how you respond to therapy and how the cancer behaves. It may help researchers better match future treatments to the biology of your tumor.

This study looks at how breast reconstruction (rebuilding the breast shape) affects women who have had a mastectomy and need radiation therapy. It aims to see if reconstruction can be done safely and with good results when followed by radiation.

This study looks at proteins and imaging patterns (from tissue, fluid near the tumor, and blood) to better understand breast cancer markers. It may help researchers find clues that doctors can use to evaluate breast nodules and newly diagnosed invasive breast cancer.

This trial is studying tiny molecules in your blood (called microRNAs) to see if they can predict how well breast cancer responds to chemotherapy given before surgery. If you are starting neoadjuvant chemotherapy, this study may help personalize your treatment.

This trial tests a new way to mark the area where breast cancer is removed during lumpectomy with oncoplastic reconstruction. The goal is to make follow-up radiation more precise and reduce the need for additional surgeries.