Testing SG after T-DXd in ER+/HER2-low metastatic breast cancer
Treatments studied
Part of Cancer, Skin clinical trials.
This trial tests whether a different chemotherapy drug, called sacituzumab govitecan (SG), can help people with ER+/HER2-low metastatic breast cancer who have already been treated with trastuzumab deruxtecan (T-DXd). It also looks at genetic markers in your tumor to predict who might benefit from SG.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have ER-positive, HER2-low breast cancer that has spread to other parts of the body (metastatic) or cannot be removed by surgery.
- You have already received hormone therapy plus a CDK4/6 inhibitor, and then trastuzumab deruxtecan (T-DXd) as your last chemotherapy before this trial.
- Your tumor can be safely biopsied (a small sample taken with a needle) for genetic testing.
- You are in good enough health to be up and about at least half the day (ECOG 0-2).
- Your blood counts, kidney, and liver function are within acceptable ranges.
- You do not have active, uncontrolled brain metastases, and any prior brain metastases are stable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial tests a new drug, Sacituzumab Govitecan, for people with advanced triple-negative breast cancer that hasn't been treated yet. The goal is to see if it can shrink tumors or slow the cancer's growth.
This study is testing a drug called sacituzumab govitecan (SG) for people with advanced triple-negative breast cancer who have already had other treatments. The goal is to see how well the drug works and what side effects it causes, using your tumor samples to look for clues (biomarkers).
This study follows patients with breast cancer that has spread to the brain and who have already received the drug Sacituzumab Govitecan (SG). The goal is to learn how well SG works in real-world settings and to see how patients are doing over time.
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This trial tests whether adding atropine to the chemotherapy drug sacituzumab govitecan can reduce side effects and improve tolerability in people with advanced triple-negative or hormone receptor-positive/HER2-negative breast cancer. It is for patients whose cancer has spread and cannot be removed surgically.
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