Genes and proteins in hard-to-treat epilepsy patients
Part of Brain & nervous system, Injuries & trauma clinical trials.
This study looks at genes, proteins, and other body chemicals in people with drug-resistant epilepsy (seizures that continue despite trying multiple medications). By studying samples from people who are already having SEEG surgery to find where seizures start, researchers hope to discover new clues about what makes epilepsy hard to treat. The results may help develop better tests or treatments in the future.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 14 and 60 years old and of Han Chinese ethnic background.
- You must have drug-resistant epilepsy — meaning your seizures have continued despite trying at least two appropriate seizure medications.
- You must be scheduled for a procedure called SEEG (stereoelectroencephalography), where fine wires are placed in the brain to find where your seizures start.
- You cannot have a progressive brain disease such as a degenerative disorder or a growing brain tumor.
- You must not have significant heart, liver, or kidney disease, severe side effects from your current seizure medications, significant intellectual disability, or a history of alcohol or drug abuse.
- You must be able to undergo MRI safely — this means no pacemaker, metal implants, or severe claustrophobia that prevents an MRI.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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