Testing mRNA Japanese encephalitis vaccines in healthy adults
Part of Brain & nervous system, Infections clinical trials.
This trial tests two new mRNA vaccines for Japanese encephalitis, a brain infection spread by mosquitoes. It aims to find the safest and most effective dose in healthy adults, with a first stage in younger adults and a second stage in all adults.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 55 years old (for Stage 1) or 18 years or older (for Stage 2).
- You are generally healthy, with no serious medical conditions, and have a body mass index (BMI) between 18.5 and 29.9.
- You have never had a Japanese encephalitis vaccine or a vaccine for similar viruses like dengue, yellow fever, or West Nile.
- You are not pregnant, breastfeeding, and you agree to use effective birth control for the study duration.
- You have no history of severe allergic reactions, bleeding disorders, or heart inflammation (myocarditis).
- You are not currently smoking (for Stage 1) and have not received other vaccines within 4 weeks before the study starts.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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