Isotretinoin for improving sperm in infertile men
Treatments studied
Part of Hormones & metabolism, Women’s health & pregnancy clinical trials.
This study tests whether a low dose of isotretinoin (a vitamin A derivative) can improve sperm production in men with low sperm counts. It may help men who haven't been able to conceive with their partner after a year of trying.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a man between 21 and 55 years old.
- You and your partner have been trying for a baby for over 1 year without success (and she has normal fertility tests).
- Two separate semen tests show fewer than 10 million total moving sperm.
- You are not currently taking any medications for depression, acne (like Accutane), or high cholesterol.
- You do not have a known genetic cause of infertility or a history of serious mental health problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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