Psilocybin for Depression and Suicidal Thoughts in Bipolar II
Treatments studied
Part of Mental health clinical trials.
This trial tests if two doses of psilocybin, given under medical supervision, are safe and acceptable for people with Bipolar II disorder who have mild to moderate depression and certain suicidal thoughts. The goal is to see if it may help improve mood and reduce suicidal thinking.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 25 to 69 years old.
- You have been diagnosed with Bipolar II disorder (a type of bipolar where you have depression and less severe highs).
- You currently have mild to moderate depression and some suicidal thoughts (like feeling you are a burden or don't belong).
- You are willing to slowly stop certain medications (like antidepressants, mood stabilizers, or cannabis) for the study period, starting 5 weeks before the psilocybin doses, and be off them for at least 2 weeks before each dose.
- You pass a medical checkup (physical exam, heart test, blood draw, urine test, and psychiatric evaluation).
- You can attend all study visits and complete questionnaires without help.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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