Psilocybin therapy for depression
Treatments studied
Part of Mental health clinical trials.
This study tests if psilocybin (a psychedelic) combined with cognitive behavioral therapy (CBT) can help people with major depression. You would receive the psilocybin in a supervised setting and have talk therapy before and after.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 21 and 60 years old.
- You have current or past major depression episodes and have active depression symptoms.
- You can swallow capsules and have a support person to drive you home after sessions.
- You are not taking antidepressants or other serotonergic substances, and have not used psychedelics or ketamine in the past year.
- You have no personal or family history of psychosis, bipolar disorder, certain personality disorders, or serious heart conditions.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a treatment called psilocybin (a hallucinogen that can help with depression) combined with group therapy can improve symptoms of depression. It requires participants to have significant depression symptoms and a support person to drive them home after each session.
This trial tests whether a medicine called psilocybin (the active ingredient in 'magic mushrooms') combined with therapy can help treat depression. You would have a few sessions with a therapist and receive the medicine in a safe setting, which might improve your mood.
This study tests whether a single dose of psilocybin (a psychedelic compound) can help treat depression by looking at brain changes on MRI. It is designed for people with moderate-to-severe depression who have not responded well to other treatments.
This trial tests whether psilocybin can help people with major depression who are currently having a depressive episode. It aims to understand how the treatment works and if it is safe and effective.
This trial tests whether taking very small, repeated doses of psilocybin (a substance found in magic mushrooms) along with talk therapy can help people with depression that hasn't gotten better with other treatments. You'll need to stop your current depression medications and avoid drugs or alcohol for the study period.
This trial tests whether a single dose of psilocybin can help people with treatment-resistant depression by changing how they focus on themselves. It aims to understand how psilocybin affects brain activity and self-related thinking.
Hear when a new Major Depressive Diorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.