HDAC inhibitor with chemoimmunotherapy before colon cancer surgery
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests adding an HDAC inhibitor to standard chemotherapy and immunotherapy before surgery for a type of colon cancer called pMMR that has grown into nearby fat or deeper. The goal is to see if this combination can shrink the tumor more effectively and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have colon adenocarcinoma confirmed by a biopsy.
- Your tumor is high-risk, meaning it has grown into the fat around the colon (T3 with at least 5 mm into fat) or into nearby organs (T4).
- The lower edge of your tumor is at least 12 cm from the anus.
- You have not had any prior cancer treatment like chemotherapy, radiation, or surgery.
- You are in good overall health (ECOG score 0 or 1) and your organ function is adequate.
- You do not have a history of autoimmune disease or certain infections like active hepatitis B or C.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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