How many doses of dexamethasone before knee replacement?
Treatments studied
Part of Bones, joints & muscles clinical trials.
This trial compares different numbers of doses of dexamethasone (a steroid that reduces inflammation) given around the time of knee replacement surgery. It aims to find the best balance of pain control and side effects.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You are scheduled for a total knee replacement (first-time replacement of the whole knee joint).
- You have not used any steroid medication (like prednisone) in the 3 months before surgery.
- You do not have inflammatory arthritis (like rheumatoid arthritis or lupus).
- You do not have a current fungal infection anywhere in your body.
- You do not have kidney or liver failure.
- You have never had a bad reaction to a corticosteroid medication.
- Your knee replacement surgery does not require removing any existing metal or plastic parts.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares two ways of giving dexamethasone (a strong anti-inflammatory) for people having knee replacement surgery. One group gets a pill and the other gets an IV. The goal is to see which method works better for pain, swelling, and recovery.
This trial tests whether taking dexamethasone by mouth can reduce pain and nausea after total knee replacement surgery. If you’re eligible, it may help improve comfort during your recovery period.
This study compares different ways of giving steroid medicine after a total knee replacement to see which approach works best and is well-tolerated. You may qualify if you’re getting a first (not repeat) knee implant and can follow the study steps.
This study tests whether a single dose of steroids (dexamethasone) given during hip replacement surgery can improve your recovery and quality of life. It may help reduce pain and swelling after the procedure.
This study tests whether adding a steroid medication (dexamethasone) through an IV line during hip replacement surgery reduces pain afterward. Researchers will compare three different doses to see which works best when combined with a nerve block (numbing medicine injected near the hip).
This study compares different doses of a corticosteroid (an anti-inflammatory medicine) injected into the knee during total knee replacement surgery. The goal is to see which dose provides the best pain relief after surgery. It is for people having their first knee replacement due to osteoarthritis.
Hear when a new Arthropathy of Knee trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.