Comparing corticosteroid doses in knee replacement pain relief injection
Part of Bones, joints & muscles, Hormones & metabolism, Pain clinical trials.
This study compares different doses of a corticosteroid (an anti-inflammatory medicine) injected into the knee during total knee replacement surgery. The goal is to see which dose provides the best pain relief after surgery. It is for people having their first knee replacement due to osteoarthritis.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and having knee replacement surgery for the first time on one knee due to osteoarthritis (wear and tear).
- Your overall health is good enough for surgery based on a standard assessment (ASA class 1, 2, or 3).
- You have not had prior surgery or infection on that knee, and you do not have other types of arthritis (like rheumatoid or septic arthritis).
- Your knee does not have a severe bend (>30°) or severe bowing/malalignment (>30°).
- You are not allergic to the study medicines (corticosteroids or anesthetics), you have not used strong opioids weekly for months, and you are not pregnant or breastfeeding.
- You have well-controlled blood sugar (HbA1c <12%) and blood pressure (<170/110), and have not had a heart attack, stroke, or other major heart event in the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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