Better embryo genetic testing for couples without an affected child
This trial is testing a new, more efficient way to perform genetic testing on embryos (PGT-M) for couples who do not have a DNA sample from an affected child. It aims to help families where standard methods are difficult, such as when the carrier has no symptoms, or when the female partner has low egg reserve.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a couple planning to use PGT-M (genetic testing of embryos) without having a DNA sample from an affected child (proband).
- You must have difficulty identifying the carrier parent's genetic pattern, such as: a carrier with no symptoms, healthy parents with affected children, low egg reserve in the female partner, or an X-linked condition with an extra X chromosome.
- You cannot use any other affected relative's DNA for testing.
- You are not seeking PGT-M for non-genetic reasons (non-PGT-M families).
- You are willing to consider haplotype analysis (genetic tracking) and do not insist only on direct Sanger testing of embryos.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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