Adding antibiotics to first chemo for advanced colorectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests whether adding a short course of antibiotics to your standard first chemotherapy for stage 4 colorectal cancer can improve treatment. The antibiotics target certain gut bacteria that might affect how well the chemo works.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with stage 4 colorectal cancer that has spread to other parts of the body.
- Your cancer can be measured on scans (RECIST 1.1 criteria).
- You are about to start your first round of chemotherapy with a 5FU-based two-drug combination (for example, FOLFOX or FOLFIRI).
- You are generally able to care for yourself (ECOG performance status 0, 1, or 2).
- You have adequate blood counts and liver and kidney function, as shown by lab tests.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests putting a chemo drug (fluorouracil) directly into the colon through a tube. It's for people with colorectal cancer who are already getting other cancer treatment, to see if adding local chemo helps shrink the main tumor.
This trial tests a combination of liposomal irinotecan, two chemotherapy drugs (leucovorin and 5-fluorouracil), and bevacizumab as a second-line treatment for people with colorectal cancer that has spread and cannot be removed by surgery.
This trial tests whether adding the immunotherapy drug atezolizumab (Tecentriq) to standard chemotherapy (FOLFOXIRI) and bevacizumab (Avastin) is more effective as a first treatment for people with a specific type of metastatic colorectal cancer that has a high immune score and is mismatch repair proficient.
This trial tests whether adding a fecal microbiota transplant (FMT) to standard first-line chemotherapy can help shrink or control advanced colorectal cancer that cannot be surgically removed. FMT is a procedure that introduces healthy donor bacteria into your gut to possibly boost your body's response to treatment.
This trial tests two different chemotherapy regimens (FOLFOX8 and mFOLFOX6), each paired with a targeted drug (bevacizumab or cetuximab), to treat colorectal cancer that has spread and cannot be surgically removed. The goal is to find which combination works best as a first treatment.
This trial tests a combination of a probiotic (Lactobacillus johnsonii), two chemotherapy drugs (CapeOX), and an immunotherapy (pembrolizumab) for people with a specific type of advanced colorectal cancer that has not responded to previous treatments. It aims to see if this mix can help control the cancer.
Hear when a new Colorectal cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.