New drug combo for first treatment of HER2-positive stomach cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a new targeted drug (TDXd) combined with chemotherapy, pembrolizumab, and trastuzumab for people with HER2-positive stomach or gastroesophageal junction cancer that has spread or cannot be removed by surgery. It aims to see if this combination works better than standard treatments as a first therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have advanced or metastatic HER2-positive stomach or gastroesophageal junction cancer that hasn't been treated yet.
- You need to have a tumor sample tested to confirm HER2 and PD-L1 status.
- You must be at least 18 years old.
- You must have at least one measurable tumor on a CT or MRI scan.
- You cannot have had prior HER2-targeted therapy (except possibly in certain situations).
- You must have adequate heart function (LVEF at least 50%).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests adding a new drug, HLX22, to the standard combination of trastuzumab and chemotherapy for people with HER2-positive stomach or gastroesophageal junction cancer that hasn't been treated yet. The goal is to see if this three-drug mix works better than the usual two-drug approach.
This trial tests a new combination of drugs (RC48, sintilimab, and SOX chemotherapy) for people with stomach or gastroesophageal junction cancer that cannot be removed by surgery, has not been treated before, and has a specific HER2 score (1+ or 2+). The goal is to shrink the tumor enough to possibly allow surgical removal.
This trial tests a combination of three drugs (targeted therapy, immunotherapy, and chemotherapy) before and after surgery for locally advanced HER2-positive stomach cancer. It aims to see if this treatment can improve outcomes for patients whose cancer has not yet spread.
This trial tests if trastuzumab deruxtecan, a targeted drug, can help people with HER2-positive stomach or gastroesophageal junction cancer who still have cancer cells detected after surgery and chemotherapy. It aims to prevent the cancer from coming back.
This trial tests adding pembrolizumab to standard trastuzumab and chemotherapy for people with HER2-positive stomach or esophageal cancer that can be fully removed with surgery. The goal is to see if this combination improves outcomes before and after surgery.
This trial tests a new immunotherapy called rilvegostomig combined with standard chemotherapy and a targeted therapy (trastuzumab deruxtecan) for people with advanced HER2-positive stomach or gastroesophageal junction cancer that has not been treated before.
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