Rulonilimab + Chemo for Advanced Cervical Cancer
Part of Cancer, Women’s health & pregnancy clinical trials.
This trial tests a new drug called Rulonilimab combined with chemotherapy, with or without bevacizumab, as the first treatment for cervical cancer that has spread or come back. It’s for people whose tumors have a specific marker (PD-L1) and who haven’t had other treatments for advanced disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with advanced or recurrent cervical cancer that is PD-L1 positive (a test showing certain protein levels).
- You have not had any prior chemotherapy, immunotherapy, or targeted therapy for advanced or recurrent disease.
- You are 18 years or older and able to perform daily activities with little or no help (ECOG score 0 or 1).
- You have at least one tumor that can be measured on a CT or MRI scan and you haven't had radiation to that area (unless the tumor grew after radiation).
- You can provide a tissue sample (like from a previous biopsy) and your blood, liver, kidney, and thyroid function are within safe ranges.
- You do not have certain other cancer types (like mucinous or clear cell) or serious health issues like uncontrolled infections, heart problems, or autoimmune diseases.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new immunotherapy drug, serplulimab, for people with locally advanced cervical cancer. The goal is to see if it can help shrink or control the cancer before standard treatments.
This trial tests a combination of cadonilimab (an immune-boosting drug) plus chemotherapy for locally advanced cervical cancer that hasn't been treated before. The goal is to see if this combination helps shrink tumors and improve outcomes before surgery.
This Phase 2 trial tests cadonilimab (an immunotherapy) combined with nab-paclitaxel (chemo) to treat cervical cancer that has come back or spread and did not respond to prior immune checkpoint medicines. It may help shrink tumors and improve disease control after prior immunotherapy failure.
This Phase 2 trial tests cadonilimab (an immunotherapy medicine) combined with anlotinib (a targeted drug) for advanced or recurrent cervical cancer that has already been treated. It may help shrink tumors or slow cancer growth, especially if the cancer has a measurable area doctors can track.
This trial tests a new combination treatment for cervical cancer that has come back or spread. It may be an option for people who have not had previous systemic therapy for this stage of cancer.
This trial tests whether combining chemotherapy with immunotherapy before surgery can help treat cervical cancer that is PD-L1 negative. It's for women with larger tumors (stage IB3 to IIB) who have not been treated yet.
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