Reducing vancomycin in NICU babies

This early-phase study tests whether the antibiotic vancomycin can help children with primary sclerosing cholangitis or biliary atresia, and related gut/bile duct problems. It may work by changing gut bacteria, but you would need to avoid certain medicines beforehand.

This study is a survey and quality-improvement effort in participating children’s intensive care units. It aims to understand and change how doctors decide to start vancomycin (an antibiotic) when sepsis is suspected, to improve care and avoid unnecessary use.

This study tests a personalized dosing approach for the antibiotic vancomycin given to patients in the neurological ICU. It aims to find the right dose for each patient to improve treatment and reduce side effects.

This trial tests a different way of giving vancomycin to children with sepsis to reduce the risk of kidney injury. It compares standard dosing to an approach that adjusts dose based on how the kidneys are working.

This study is testing a way to reduce the chance of a certain breathing problem (called NAV) in babies who need a breathing machine in the NICU. If your baby has been on the machine for two days or more, they may be able to join.

This trial studies a better way to monitor and adjust vancomycin (an antibiotic) dosing in very young infants. It may help your baby get the right dose while reducing the risk of under- or over-dosing.