Study of chemo plus immunotherapy for localized rectal cancer before surgery
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests a combination of chemotherapy (FOLFOX) and two immunotherapies (botensilimab and balstilimab) before surgery for patients with localized rectal cancer. It aims to see if adding immunotherapy helps shrink the tumor and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- You have rectal adenocarcinoma (cancer) that hasn't spread to distant organs.
- Your rectal tumor is within about 5 inches of your anal opening and hasn't threatened the surrounding tissue by more than 3 mm.
- You haven't had any prior treatment for your rectal cancer, such as chemotherapy or radiation.
- Your blood counts, kidney, and liver function are within certain safe ranges.
- You do not have an active autoimmune disease or other serious illness that would interfere.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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