Obinutuzumab vs standard treatment for membranous nephropathy
Treatments studied
Part of Immune system & allergy, Kidney & urinary clinical trials.
This trial tests a new antibody drug (obinutuzumab) against a standard treatment (cyclophosphamide plus steroids) for people with a kidney condition called primary membranous nephropathy that causes protein leakage. The goal is to see which treatment better reduces protein loss and protects kidney function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- Your kidney disease is primary membranous nephropathy (confirmed by a kidney biopsy or a positive blood test for anti-PLA2R antibodies).
- You have high protein in your urine (at least 4 grams per day) and low albumin in your blood despite taking blood pressure medicines for several months.
- Your kidney function (eGFR) is 40 or higher.
- Your protein levels have not recently dropped by half on their own.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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