Comparing two anti-nausea drugs before weight-loss surgery
Part of Digestive system clinical trials.
This trial compares two medications, cyclizine and metoclopramide, given before bariatric surgery to see which one better reduces the amount of fluid left in the stomach (gastric residual volume). This matters because a full stomach during surgery can increase the risk of complications. If you qualify, you'll receive one of these medications randomly, and the results may help improve safety for future patients.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 40 years old.
- Your body mass index (BMI) is between 40 and 50. (BMI is a measure of body fat based on height and weight.)
- You are classified as ASA III, meaning you have a severe systemic disease that limits activity but is not incapacitating.
- You are scheduled for bariatric (weight-loss) surgery.
- You are a non-smoker.
- You do not have conditions that delay stomach emptying, such as long-standing diabetes (over 5 years), certain nerve or muscle diseases, or gastrointestinal issues like reflux or hiatal hernia.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two types of weight-loss surgery to see how they affect hormones after a meal. It may help you choose a surgery that improves your health and weight loss.
This trial tests whether giving a drug called metoclopramide before surgery can help your stomach empty faster in people taking GLP-1 weight-loss medications. This may reduce the risk of food or liquid staying in your stomach during surgery, which can be dangerous.
This study tests two different medication combinations to prevent nausea and vomiting after laparoscopic gallbladder removal surgery. You'll receive either ondansetron plus metoclopramide, or dexamethasone plus metoclopramide, and researchers will track how quickly you need rescue medication if nausea occurs.
This trial tests a medicine given before emergency surgery to see if it helps prevent nausea and vomiting after the operation. It compares the medicine alone with the medicine plus a steroid to find the better approach.
This study tests whether drinking a special carbohydrate drink before weight-loss surgery can help your stomach and intestines recover faster after the operation. If you have metabolic syndrome and are planning certain types of bariatric surgery, this may help you improve your recovery.
This study compares giving ondansetron (a nausea medicine) through a vein versus injecting it near a nerve to prevent nausea and vomiting after weight loss surgery. It may help identify which method works best for patients undergoing laparoscopic sleeve gastrectomy.
Hear when a new Bariatric Surgery trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.