Lithium treatment for Cornelia de Lange syndrome
Treatments studied
Part of Brain & nervous system, Genetic & congenital clinical trials.
This trial tests whether lithium can help people with Cornelia de Lange syndrome (CdLS) who have a confirmed NIPBL gene mutation. It might improve their daily life and overall well-being.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You or your child must be older than 4 years old
- Body weight should be in the normal range for CdLS based on age and height
- Diagnosis of CdLS must be confirmed by clinical criteria and a NIPBL gene mutation
- Medications must be stable for at least 4 weeks before starting the study
- You need a parent or legal guardian to sign a consent form
- The study drug can be taken as capsules, drops, or mixed with food or drinks to help with swallowing
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether N-acetylcysteine (a supplement) can reduce repetitive or self-injurious behaviors in people with Cornelia de Lange syndrome. It involves 4 hospital visits over 18 weeks.
This study tests a structured behavior assessment and treatment program for children with Cornelia de Lange syndrome who have challenging behaviors. It may help reduce self-injury, aggression, and disruptive behavior through a plan families can carry out.
This study tests a new way to deliver lithium, a common treatment for bipolar disorder, using tiny gold particles. It aims to see if this method is safe and effective in laboratory models, which may lead to better treatments with fewer side effects.
This trial tests whether taking lithium for 2 years can improve symptoms in people with a TBR1 gene change that causes neurodevelopmental challenges. It aims to see if lithium is safe and helpful for this condition.
This trial tests if lithium can help prevent mood episodes from returning in people with bipolar disorder or major depressive disorder. It aims to see if lithium is a safe and effective longer-term treatment.
This trial tests a drug called aprepitant to see if it can help people with CLIFAHDD, a rare genetic condition that affects movement and development. The study will check if the drug is safe and if it improves symptoms.
Hear when a new Cornelia de Lange Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.