Behavior plan study for children with Cornelia de Lange syndrome
Part of Brain & nervous system, Genetic & congenital clinical trials.
This study tests a structured behavior assessment and treatment program for children with Cornelia de Lange syndrome who have challenging behaviors. It may help reduce self-injury, aggression, and disruptive behavior through a plan families can carry out.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your child has a confirmed diagnosis of Cornelia de Lange syndrome
- Your child is age 3 to 15 and can take part for several hours of visits
- Your child speaks English (or the study is done in English for your family)
- If you join the treatment group: your child has problem behaviors like self-injury, aggression, and/or disruption
- If you join: you as a parent/guardian are English-speaking and willing to attend 2 full clinic days and 1 half-day, complete questionnaires, and try the behavior plan
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 trial tests whether a supplement-like medicine called N-acetylcysteine (NAC) can reduce repetitive behaviors and self-injurious behaviors in people with Cornelia de Lange syndrome (CdLS). It also checks safety over about 18 weeks at Johns Hopkins Hospital.
This trial tests whether lithium can help people with Cornelia de Lange syndrome (CdLS) who have a confirmed NIPBL gene mutation. It might improve their daily life and overall well-being.
This trial tests a structured (manualized) assessment and treatment approach for children who have very frequent challenging behaviors despite prior help. It aims to reduce these behaviors and improve daily functioning by targeting what keeps the behavior going.
This study looks at how to reduce serious problem behaviors (including self-injury) in children who have it many times per day even after previous treatment. It may help if your child’s behavior is driven by social attention or other positive effects and they can stay on the same supports, school plan, and medicines during the study.
This study tests an improved version of functional communication training for children ages 3 to 17 whose destructive behavior (like hitting or yelling) happens often and is fueled by social attention. It aims to help children learn better ways to get attention instead of using hard-to-manage behaviors.
This study looks at basic and applied methods to understand “extinction bursts,” times when a hard-to-control behavior may briefly get worse before it improves. It may help families and clinicians choose safer, more effective behavior supports for children with very frequent problem behaviors.
Hear when a new Cornelia de Lange Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.