SBRT and immunotherapy for colorectal cancer liver metastases
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial combines targeted radiation (SBRT) with an immunotherapy drug (PD-1 inhibitor) to treat colorectal cancer that has spread to the liver and can't be removed by surgery. It aims to help shrink or control tumors in patients whose cancer has a normal DNA repair system (pMMR/MSS).
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your colorectal cancer has spread to the liver and a surgeon says it cannot be fully removed by surgery.
- Your liver tumors are 6 cm or smaller and can be seen on scans.
- You have at least 700 cc of healthy liver outside the area being treated with radiation.
- You have not had prior radiation to the liver or nearby tissue.
- Your liver function is good (Child-Pugh score A or better) and you have not had active hepatitis or cirrhosis.
- You have not had previous treatment with PD-1 or similar immunotherapy drugs.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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