PD-1 inhibitor combined with apatinib and mitotane for advanced adrenal cancer
Treatments studied
Part of Cancer, Hormones & metabolism clinical trials.
This trial tests a new combination of drugs (PD-1 inhibitor, apatinib, and mitotane) for people with advanced adrenal cortical carcinoma that cannot be removed by surgery. The goal is to see if this combination is safe and effective for those who have not yet received standard first-line treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with adrenocortical carcinoma (a rare cancer of the adrenal gland).
- Your cancer is advanced and cannot be removed by surgery, and you have not yet received standard first-line treatment.
- You are between 18 and 70 years old.
- You are in generally good health (able to perform daily activities without help).
- You have at least one measurable tumor (visible on scans).
- Your blood counts, liver, kidney, and heart function are within acceptable ranges (confirmed by tests).
- You are willing to use effective contraception (if applicable) during the study and for several months after.
- You do not have a history of other cancer within the past 5 years (except some cured skin or thyroid cancers).
- You have not had certain prior treatments (immunotherapy, TKI drugs, or other experimental drugs) in the recent past.
- You do not have active infections, autoimmune diseases, or uncontrolled health conditions like high blood pressure or heart problems.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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