PPIs for bleeding varices in liver disease
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether proton pump inhibitors (PPIs) can help people with cirrhosis who are hospitalized for variceal bleeding. It looks at whether PPIs reduce complications during the hospital stay.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be an adult (18 years or older)
- You have been diagnosed with cirrhosis (scarring of the liver)
- You are currently having bleeding from enlarged veins in your throat or stomach (varices), confirmed by endoscopy
- You have signs of low blood pressure from blood loss (hypovolemic shock)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether a common acid-reducing medicine (a proton pump inhibitor) helps people with cirrhosis who are having bleeding from enlarged veins in the esophagus. The goal is to see if it improves outcomes after emergency treatment.
This trial tests whether a heartburn medication (pantoprazole) helps patients with liver cirrhosis who have had a procedure to treat enlarged veins in the esophagus or stomach. It looks at how well the medicine works when given after this procedure to prevent complications.
This study tests a preventive procedure called TIPS, which places a small tube in the liver to lower blood pressure and prevent re-bleeding. It may help people with cirrhosis who have just had bleeding from stomach varices by reducing the chance of another bleed.
This trial studies better ways to use endoscopy and other treatments to stop bleeding in the stomach or esophagus caused by high blood pressure in the liver (portal hypertension). It may help if you have been diagnosed with portal hypertension and have varices (enlarged veins) in your esophagus or stomach.
This trial tests whether taking a high dose of omeprazole by mouth can help control bleeding from a peptic ulcer that looks high-risk on endoscopy. It may be aimed at lowering the chance of bleeding again after your procedure.
This study compares two ways to prevent future bleeding from enlarged veins in the esophagus or stomach in people with liver cirrhosis. One method uses a small tube (called TIPS) to reduce pressure in the liver, and the other combines a banding procedure with medication. The goal is to see which approach works better.
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