Proton pump inhibitor treatment for bleeding varices in cirrhosis
Part of Digestive system clinical trials.
This study tests whether taking a proton pump inhibitor (a medicine that lowers stomach acid) helps people with liver cirrhosis who have sudden bleeding from enlarged esophagus veins (varices). It may help reduce bleeding and complications by changing stomach/upper digestive tract conditions during this urgent time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have liver cirrhosis (scarring of the liver).
- Your problem causing high pressure in the portal vein is from cirrhosis.
- You are having sudden (acute) bleeding from esophagus varices, confirmed by an emergency endoscopy within 24 hours.
- You agree to join the study, follow its rules, and sign informed consent.
- You have NOT been on a proton pump inhibitor (PPI) for more than 2 weeks before coming in.
- You do NOT have serious exclusions like pregnancy, significant kidney disease, major heart/lung problems, or an allergy to PPIs.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether proton pump inhibitors (PPIs) can help people with cirrhosis who are hospitalized for variceal bleeding. It looks at whether PPIs reduce complications during the hospital stay.
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This trial compares two approaches to prevent future bleeding from enlarged veins in the esophagus (food pipe) in patients with liver cirrhosis who have already had one bleeding episode. You'll receive either an endoscopic procedure with medication or a minimally invasive vein procedure, to see which works better long-term.
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