Preventing repeat bleeding from veins in cirrhosis
Part of Brain & nervous system, Digestive system, Hormones & metabolism clinical trials.
This study compares two ways to prevent future bleeding from enlarged veins in the esophagus or stomach in people with liver cirrhosis. One method uses a small tube (called TIPS) to reduce pressure in the liver, and the other combines a banding procedure with medication. The goal is to see which approach works better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must have a liver condition called cirrhosis, which is scarring of the liver.
- You must have had a recent bleeding event from enlarged veins in your esophagus (called varices) or from a specific type of vein near the stomach (called type 1 gastroesophageal varices).
- You must have recovered from this bleeding episode and be stable enough to start preventive treatment.
- You must not have had certain previous liver procedures, like TIPS, or have certain other medical conditions that would make this study unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether placing a TIPS (a small tube in the liver to improve blood flow) early after a variceal bleed helps people with cirrhosis and a partial portal vein clot. It may reduce the risk of re-bleeding and improve outcomes.
This trial tests a slightly smaller TIPS stent (underdilated) against the standard size to see which is better at preventing another variceal bleed in people with cirrhosis and liver scarring. It aims to find the safest way to lower pressure in the veins while reducing side effects.
This study tests a preventive procedure called TIPS, which places a small tube in the liver to lower blood pressure and prevent re-bleeding. It may help people with cirrhosis who have just had bleeding from stomach varices by reducing the chance of another bleed.
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This study tests a new way to treat bleeding varicose veins in the stomach by using endoscopic ultrasound to guide the procedure, for people with liver cirrhosis. It aims to improve how this bleeding is managed.
This study tests whether treating enlarged veins in the food pipe or stomach (called varices) in a day-care unit, without an overnight hospital stay, is safe and feasible for people with cirrhosis. The treatment aims to prevent these veins from bleeding.
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