Clin2
NCT06861777Possibly a fitNot yet recruiting

Combination treatment before surgery for esophageal cancer

Esophageal Squamous Cell Carcinoma (ESCC)

Part of Cancer, Digestive system clinical trials.

This trial tests a combination of chemotherapy, radiation, and an immunotherapy drug called adebrelimab before surgery for esophageal cancer. The goal is to see if this treatment can shrink the tumor and improve outcomes for people with locally advanced disease.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
474 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must have esophageal squamous cell carcinoma (a type of esophageal cancer) that is confirmed by biopsy and is at a stage where surgery may be possible.
  • You must be 18 years or older and in generally good health (able to do light activity).
  • You must not have had any prior cancer treatment (like chemo or radiation) for this esophageal cancer.
  • You must be willing to receive study treatment before surgery and then have surgery.
  • You must have adequate blood counts, liver and kidney function, and be able to take part in follow-up visits.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07595770Recruiting· Phase 2
New immunotherapy combined with chemotherapy and radiation for esophageal cancer

This trial tests whether adding a new immunotherapy drug (adebrelimab) to standard chemotherapy and radiation improves outcomes for patients with esophageal squamous cell carcinoma before surgery. The goal is to shrink the tumor and improve survival.

Guangzhou, Guangdong
NCT07638436Recruiting· Phase 2
Immunotherapy with chemotherapy for advanced esophageal cancer

This trial tests whether combining a new immunotherapy drug (adebrelimab) with standard chemotherapy can help shrink borderline resectable esophageal squamous cell carcinoma before surgery. The goal is to make tumors easier to remove and improve survival.

Guangzhou, Guangdong
NCT07751055Recruiting· Phase 2
Chemotherapy and radiation with immunotherapy before surgery for esophageal cancer

This trial tests whether adding two immunotherapy drugs to standard chemotherapy and radiation before surgery can help shrink esophageal cancer and improve outcomes. It is for people with a certain type of esophageal cancer that can be removed with surgery.

Guangzhou, Guangdong
NCT07678580Not yet recruiting· Phase 2
Short-course radiation plus immunotherapy and chemo for esophageal cancer

This trial tests a new combination of short-course radiation, an immunotherapy drug (tislelizumab), and chemotherapy before surgery for esophageal cancer. It aims to shrink tumors and improve surgical outcomes.

Xi'an, Shaanxi
NCT06869213Recruiting· Phase 2
Adebrelimab plus chemo before and after surgery for esophageal cancer

This trial tests a combination of the immunotherapy drug adebrelimab (SHR-1316) and chemotherapy given before and after surgery for locally advanced esophageal squamous cell carcinoma that can be removed. The goal is to see if this approach helps shrink the tumor and improves outcomes.

Beijing
NCT07493993Not yet recruiting· Phase 2
Immunotherapy plus chemo before surgery for esophageal cancer

This trial tests whether combining two immunotherapy drugs (which boost your immune system to fight cancer) with a standard chemotherapy drug before surgery can improve outcomes for people with esophageal cancer that can be removed. The goal is to see if this approach shrinks the tumor and helps you live longer.

Tianjin, Tianjin Municipality

Hear when a new Esophageal Squamous Cell Carcinoma (ESCC) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.