Clin2
NCT06881017Possibly a fitNot yet recruiting

Personalized treatment for advanced stomach cancer

Gastric CancerHER2 + Gastric CancerCLDN18.2-positive Adenocarcinoma of the Gastroesophageal JunctionPD-L1 Positive

Treatments studied

Part of Cancer, Digestive system clinical trials.

This study tests whether giving treatment based on the specific markers of your tumor can better control advanced stomach cancer. The goal is to match the right therapy to each person's cancer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
140 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 or older.
  • You have advanced stomach cancer or cancer at the junction of the stomach and esophagus.
  • You have not had systemic treatment for advanced disease, but if you relapsed more than 6 months after finishing prior therapy, you may be eligible.
  • You have at least one measurable tumor lesion.
  • You have a tumor tissue sample available for biomarker testing (HER2, CLDN18.2, and PD-L1).
  • You are physically active (ECOG 0-1) and expected to live at least 3 months.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06791148Recruiting· Phase 2
Low-dose radiation plus chemo and immunotherapy for advanced stomach cancer

This trial tests a combination of low-dose radiation, chemotherapy, and an immunotherapy drug (AK112) for people with advanced stomach or gastroesophageal junction cancer that has progressed after first-line treatment. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.

Nanjing, Jiangsu
NCT06102772Recruiting
Combination immunotherapy and targeted therapy for advanced gastric cancer

This trial tests a combination of three drugs—adebrelimab (an immunotherapy), fruquintinib (a targeted therapy to cut off blood supply to the tumor), and a chemotherapy (paclitaxel or albumin-bound paclitaxel)—in people with advanced stomach/gastric cancer whose disease has worsened after one prior chemotherapy. The goal is to see if this new mix can help control the cancer.

Tianjin, Tianjin Municipality
NCT06241469Not yet recruiting· Phase 2
Immunotherapy plus chemotherapy for advanced stomach cancer

This trial tests a combination of an immunotherapy drug (sintilimab) and two chemotherapy drugs (nab-paclitaxel and tegafur) as a first treatment for stomach or gastroesophageal junction cancer that cannot be removed by surgery or has spread. The goal is to see if this combination helps people live longer and controls the cancer better.

Changzhou, Jiangsu
NCT06349967Not yet recruiting· Phase 2
Second-line treatment for advanced stomach cancer

This trial tests a combination of two drugs—nab-paclitaxel (a chemotherapy drug) and cadonilimab (an immunotherapy drug)—for people with advanced stomach cancer that has spread to the lining of the abdomen. The goal is to see if this combination can help shrink or control the cancer when other treatments haven't been tried yet.

NCT06630130Recruiting· Phase 2
Surgery and drug therapy for advanced stomach cancer

This trial tests whether combining different drugs before and after surgery can help people with locally advanced stomach cancer that can't be removed right away. The goal is to see which combination works best to shrink the tumor and improve outcomes.

Seoul
NCT06760858Recruiting
Study of treatment for advanced stomach cancer

This study tests a treatment approach for stomach cancer that hasn't spread to other organs. It's for people who have not had any prior cancer treatments and are in relatively good health.

Chongqing, Chongqing Municipality

Hear when a new Gastric Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.