Clin2
NCT06889649Possibly a fitRecruiting

SBRT plus immunotherapy and targeted therapy for kidney cancer

Radiation TherapyTargeted TherapyImmunotherapyRenal Cancer Metastatic

Treatments studied

Part of Cancer, Kidney & urinary clinical trials.

This trial tests a combination of targeted therapy (axitinib) and immunotherapy (toripalimab) alongside stereotactic body radiation therapy (SBRT) for kidney cancer that has come back or spread. It may be an option if you have a limited number of metastatic tumors that can be treated with radiation.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
30 people
Ages
18 years to 80 years
Study type
Interventional

Who can take part

  • Your kidney cancer must be confirmed and have come back or spread to other parts of the body.
  • You can have up to 5 metastatic tumors, or more than 5 tumors as long as at least 3 of them can be treated with radiation.
  • Your age is between 18 and 80 years old.
  • You are expected to live for at least 12 weeks.
  • Your tumors can be measured on scans (RECIST criteria).
  • Your daily activity level is fairly good (ECOG score 0-2, meaning you can take care of yourself and are up and about at least half the day).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06583070Recruiting
SABR plus targeted therapy and immunotherapy for advanced kidney cancer

This trial tests combining a precise type of radiation (SABR) with standard targeted therapy and immunotherapy drugs for kidney cancer that has come back or spread. The goal is to see if adding radiation improves outcomes.

Beijing, Beijing Municipality
NCT07172386Recruiting· Phase 2
Pre-surgery treatment for advanced kidney cancer

This trial tests if a combination of targeted embolization, immunotherapy (Toripalimab), and a targeted therapy pill (Axitinib) can shrink advanced kidney cancer before surgery. It is for patients whose cancer has spread to nearby tissues or lymph nodes, or has limited spread elsewhere that can be removed.

Tianjin, Tianjin Municipality
NCT07630363Not yet recruiting· Phase 1/Phase 2
Atorvastatin plus axitinib and toripalimab for advanced kidney cancer

This trial tests whether adding a cholesterol-lowering drug (atorvastatin) to the standard combination of two cancer drugs (axitinib and toripalimab) can improve outcomes for people with advanced clear cell kidney cancer that cannot be removed by surgery or has spread. The goal is to see if this three-drug approach is safe and effective.

Beijing, Chaoyang District
NCT07470840Not yet recruiting· Phase 2
Radiation plus drug therapy for advanced kidney cancer

This trial tests a combination of precise radiation (SBRT) plus two drugs (anlotinib and bimepolizumab) to see if it helps control advanced kidney cancer. The goal is to shrink tumors and slow the cancer's growth.

Fuzhou, Fujian
NCT07744932Recruiting· Phase 2
Radiation plus drug combo for kidney cancer that has spread a little

This trial tests a combination of targeted radiation, an oral drug (axitinib), and an immunotherapy (toripalimab) for people with kidney cancer that has spread to a few spots. It aims to see if this combo helps control the cancer longer.

Shijiazhuang, Hebei
NCT06255223Recruiting· Phase 2
Radiation therapy plus immunotherapy for advanced kidney cancer

This trial tests a combination of targeted radiation therapy with a restart of immunotherapy for people whose kidney cancer has grown after prior immunotherapy. It aims to see if radiation can help the immune system fight the cancer again.

Nanjing, Jiangsu

Hear when a new Radiation Therapy trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.