Clin2
NCT07172386Possibly a fitRecruiting

Pre-surgery treatment for advanced kidney cancer

Renal Cell Carcinoma (RCC)

Part of Cancer, Kidney & urinary, Women’s health & pregnancy clinical trials.

This trial tests if a combination of targeted embolization, immunotherapy (Toripalimab), and a targeted therapy pill (Axitinib) can shrink advanced kidney cancer before surgery. It is for patients whose cancer has spread to nearby tissues or lymph nodes, or has limited spread elsewhere that can be removed.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
40 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have advanced kidney cancer that has spread to nearby tissues or lymph nodes, or has limited spread that can be removed
  • You have not had prior cancer treatment like chemotherapy, radiation, or targeted therapy
  • Your cancer is measurable on scans and has not spread to the brain
  • You are in generally good health (ECOG score 0 or 1)
  • Your blood counts and organ function are within acceptable ranges
  • You agree to use effective birth control during and for 3 months after treatment

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07657325Recruiting
Toripalimab for high-risk kidney cancer that has been removed

This trial tests whether the drug toripalimab can prevent kidney cancer from coming back in people who have had their kidney and any visible metastases surgically removed. It focuses on patients with high-risk features or who had some metastatic spots taken out completely.

Tianjin, Tianjin Municipality
NCT07630363Not yet recruiting· Phase 1/Phase 2
Atorvastatin plus axitinib and toripalimab for advanced kidney cancer

This trial tests whether adding a cholesterol-lowering drug (atorvastatin) to the standard combination of two cancer drugs (axitinib and toripalimab) can improve outcomes for people with advanced clear cell kidney cancer that cannot be removed by surgery or has spread. The goal is to see if this three-drug approach is safe and effective.

Beijing, Chaoyang District
NCT05738694Recruiting· Phase 3
Test axitinib plus immunotherapy before kidney cancer surgery

This study tests whether taking axitinib plus an immunotherapy drug (PD-1) before surgery can help people with kidney cancer live longer without the cancer coming back. It’s focused on people who have a higher-risk kidney tumor based on scans and pathology findings.

Beijing
NCT06889649Recruiting· Phase 2
SBRT plus immunotherapy and targeted therapy for kidney cancer

This trial tests a combination of targeted therapy (axitinib) and immunotherapy (toripalimab) alongside stereotactic body radiation therapy (SBRT) for kidney cancer that has come back or spread. It may be an option if you have a limited number of metastatic tumors that can be treated with radiation.

Beijing, Beijing Municipality
NCT06279403Not yet recruiting· Phase 2
Immunotherapy before surgery for advanced kidney cancer

This trial tests whether giving immunotherapy before surgery can help people with advanced kidney cancer. The goal is to see if waiting on surgery and starting with medication that boosts the immune system is safe and effective.

NCT07776717Not yet recruiting· Phase 2
Immunotherapy plus targeted therapy for advanced kidney cancer

This trial tests a combination of two drugs — an immunotherapy (toripalimab) and a targeted therapy (axitinib) — as the first treatment for advanced kidney cancer. The approach may shrink the tumor before deciding whether and when to remove the kidney surgically.

Hear when a new Renal Cell Carcinoma (RCC) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.