Omitting endocrine therapy and radiation in low-risk breast cancer
Part of Cancer, Skin clinical trials.
This trial tests whether older women with very low-risk, hormone-positive breast cancer can safely skip endocrine therapy (hormone-blocking pills) and radiation after lumpectomy. It aims to maintain quality of life while keeping cancer from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 60 years or older.
- You had a lumpectomy (breast-conserving surgery) for invasive breast cancer.
- Your tumor is ER-positive, PR-positive, and HER2-negative.
- Your tumor is 3 cm or smaller with no cancer in lymph nodes.
- Your tumor has a low recurrence risk based on Ki-67 (≤20%) or Oncotype DX (0-10).
- You either never started endocrine therapy, or stopped it within 6 months of starting.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether some women with low-risk breast cancer that has spread to a few lymph nodes can safely skip radiation therapy after surgery. It aims to reduce side effects while keeping the cancer from coming back.
This trial is for women 50 and older with early-stage, hormone-positive or HER2-positive breast cancer. It tests whether it is safe to skip radiation therapy after a lumpectomy if an MRI before surgery shows the breast tissue looks a certain way.
This trial tests whether women with certain aggressive breast cancers (HER2-positive without hormone receptors, or triple-negative) can safely skip breast surgery if chemotherapy makes their tumor completely disappear. The goal is to avoid surgery and its side effects when it may no longer be needed.
This trial tests whether women aged 65 and older with a certain type of early breast cancer can safely skip chemotherapy and instead receive a pill that helps stop cancer cells from growing. The goal is to reduce treatment side effects while keeping the cancer from coming back.
This trial is testing whether it's safe to reduce the amount of radiation therapy to the lymph nodes for breast cancer patients whose lymph nodes become cancer-free after neoadjuvant (pre-surgery) treatment. The goal is to see if less radiation is just as effective and causes fewer side effects.
This trial is for women aged 55 or older with very early-stage breast cancer (stage 0 or 1) who want to save their breast. It tests giving a single dose of radiation during the lumpectomy instead of weeks of daily radiation afterward.
Hear when a new Breast cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.