Dapagliflozin for hard-to-treat fluid build-up in cirrhosis
Treatments studied
Part of Digestive system clinical trials.
This study tests a medication called dapagliflozin (a drug used for diabetes) to see if it can help people with advanced liver disease and fluid build-up in the belly that does not go away with standard care. It may offer a new way to manage this difficult condition.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have cirrhosis and fluid build-up in your belly (ascites) that does not respond to standard treatment (low-salt diet and diuretics) or comes back quickly within 4 weeks after being drained.
- You do not have low blood pressure below 90/60 or need medication to keep your blood pressure up.
- You have not had frequent urinary tract infections (2 within months or 3 within a year).
- You are not allergic to SGLT2 inhibitors (a class of diabetes drugs).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a diabetes pill (dapagliflozin) to see if it helps people with liver cirrhosis and fluid buildup (ascites). The goal is to improve fluid balance and possibly reduce hospital stays.
This Phase 2 study tests empagliflozin to see if it can improve fluid buildup (ascites) in people with cirrhosis. It may help reduce symptoms related to fluid retention, but you must meet specific safety and stability requirements.
This trial tests whether a diabetes drug called dapagliflozin can help people on peritoneal dialysis keep their remaining kidney function longer. It is for patients who started dialysis recently and still make urine.
This study tests if adding a diabetes medicine called an SGLT2 inhibitor to your current treatment can help prevent liver complications in people with chronic hepatitis B and type 2 diabetes or prediabetes. If you have early liver scarring and stable diabetes treatment, this could offer extra protection for your liver.
This trial tests if canagliflozin, a diabetes medicine, helps remove extra fluid and reduce scarring in people on peritoneal dialysis (home-based dialysis). It may improve your dialysis results and protect your belly lining.
This study tests whether a medication called dapagliflozin (a pill for heart failure) can help people with a Fontan circulation who feel short of breath. It aims to improve symptoms and quality of life.
Hear when a new Refractory Ascites trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.